Journal article
Prevalence and predictors of poor outcome in children with febrile neutropaenia presenting to the emergency department
E Long, FE Babl, N Phillips, S Craig, M Zhang, A Kochar, M McCaskill, ML Borland, MA Slavin, R Phillips, RDA Lourenco, F Michinaud, KA Thursky, G Haeusler
EMA Emergency Medicine Australasia | WILEY | Published : 2022
Abstract
Objective: Children with acquired neutropaenia due to cancer chemotherapy are at high risk of severe infection. The present study aims to describe the prevalence and predictors of poor outcomes in children with febrile neutropaenia (FN). Methods: This is a multicentre, prospective observational study in tertiary Australian EDs. Cancer patients with FN were included. Fever was defined as a single temperature ≥38°C, and neutropaenia was defined as an absolute neutrophil count <1000/mm3. The primary outcome was the ICU admission for organ support therapy (inotropic support, mechanical ventilation, renal replacement therapy, extracorporeal life support). Secondary outcomes were: ICU admission, I..
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Funding Acknowledgements
This study was funded by the National Health and Medical Research Council (NHMRC) Project Grant (AP1104527) and supported in part by a NHMRC Centre of Research Excellence Grant for the National Centre for Infections in Cancer (GNT1116876) and Paediatric Emergency Medicine (GNT1058560), Canberra, ACT, Australia. The authors gratefully acknowledge the support and endorsement of the Australian and New Zealand Children's Haematology/Oncology Group (ANZCHOG) and the Paediatric Research in Emergency Departments International Collaborative (PREDICT).